Bodyguards are fighters who protect the demon bosses. All demons have five bodyguards. Before one can actually battle the demon, they have to beat their five bodyguards. Bodyguards have their own speaking roles (except Shin).
Upon building his school, Hermit held a competition to find the one he deems worthy to be taught with his secret power. There are five fighters who compete in his competition, who act as Hermit's bodyguards. In actuality, They hold no respect for Hermit and only seek to have his secret power, with the exception of Mantis, who seeks to destroy it.
The first three of Wasp's "bodyguards" are the members of New Blood, a group consisting of crew members who had rebelled against her. The last two bodyguards are the older crew members who still serve her.
Widow's "bodyguards" are mainly composed of men who have been charmed. The only exception is Puma, a woman who serves Widow to help her achieve her ambitions. Most bodyguards attack Shadow in an attempt to eliminate the competition, because they are mistaken in the belief that Shadow desires Widow as they do; He merely wants to obtain her Demon Seal, and has no interest in her whatsoever. After being defeated by Shadow, they are released from Widow's spell.
Titan's bodyguards are the evil counterparts of Shadow from another dimensions. In those dimensions, they were not strong enough to resist the pull of Shadow Energy and ended up getting corrupted by it. After defeating the Demons, instead of moving on to the next province, they ended up staying and taking over their syndicate.