Talk:Enchantments/@comment-85.187.123.52-20180513065106/@comment-31479589-20180513071909

Depends on the situation.

If you fight many rounds in one fight, like Survival or Gates of Shadows, then defensive enchantments like Rejuvenation/Regeneration or Damage Absorption could be helpful. You can also pair it with Weakness/Enfeeble or Lifesteal for extra durability. This also can be applied if your enemy have insane damage or have Damage Return (like Butcher and Wasp).

If you fights enemy with high tankiness or crazy recovery potential (like Widow and Shogun), then you can try to put offensive enchantment on your weapon, like Time Bomb, Bleeding, or Frenzy. Basically, anything that'll help you outdamage their regen/durability.

If your enemy has a combination of immense tankiness, crazy regen, and insane damage (May and Titan), then you could use offensive one on weapon, and Damage Absorption on armors. Regeneration wouldn't help if they can kill you in 1-2 hits. Enfeeble help reducing their damage, but can't help you with the regen/durability.

For raids, Frenzy on every items are usually recommended, due to the main goal there is dealing damage. You can use defensive enchantments to make yourself able to stands more hits, but you'll sacrificing your damage potential by that.